From the oldest metal element to a versatile nanomaterial, gold a powerful element to serve human life, culture and health. Gold will be always have the irreplaceable role forever. The surface chemistry of functionalized gold nanoparticles (Au NPs) plays a crucial role in the effective utilization in health-related applications like cancer therapy. It mainly depends on the physical and chemical reactions between the molecules and gold nanoparticles. To meet the basic needs of various applications, the surface properties of gold nanoparticles can be tailored and precisely controlled [ 1 ]. Generally, these gold nanoparticles have unique physical and chemical properties, which can be widely used for a broad range of applications from prophylaxis to diagnosis and also for other treatments. Meanwhile, gold has an excellent conductivity, malleable and ductile which can make it stretchable or compressible to arbitrary shape, quite biocompatible, as some edible gold foils are added to cak...